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KMID : 0525720110160010045
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Journal of Chitin and Chitosan
2011 Volume.16 No. 1 p.45 ~ p.51
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Preparation and Characterization of Thermosensitive Hydrogel using Chitosan and Glycerol Phosphate Disodium Salt
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Park Jun-Kyu
Lee Kyoung-Jae
Son Dong-Hee
Choi Chang-Yong
Jang Mi-Kyeong
Nah Jae-Woon
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Abstract
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In this study, thermosensitve hydrogels (ChGPs) were prepared using chitosan and glycerol phosphate disodium salt hydrate (GP) for adhesion inhibitor. The chitosan with various molecular weight (Mw) was studied for biomaterials such as adhesion inhibitor. The chitosan, fractionated by ultrafiltration techniques, showed narrow Mw distributions depending on the applied ultrafiltration membranes. The ChGP hydrogels according to Mw of chitosan showed sol-gel phase transition ranging from 31oC to 37oC. Also ChGP hydrogels did not show any cytotoxic effect on the L929 cell. The results of scanning electron microscope (SEM) revealed that surface of ChGP hyrogels have a lot of porous. With these results, ChGP hydroges may be considered a potential candidate for various biomaterials such as adhesion inhibitor and drug and /or peptide delivery carriers.
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KEYWORD
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chitosan, glycerol phosphate disodium salt, thermosensitve hydrogel, biomaterial
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